abstract：:Cardiovascular disease is the number one cause of death in the U.S and results in the loss of approximately one million lives and more than 400 billion U.S. dollars for treatments every year. Recently, tissue engineered blood vessels have been studied and developed as promising replacements for treatment with autologo...

journal_title：Advances in experimental medicine and biology

authors： Chen J,Alexander GC,Bobba PS,Jun HW

更新日期：2018-01-01 00:00:00

abstract：:Besides mechanical and protective function, bone serves as a keeper for marrow cells and an organ for regulation of calcium ion homeostasis. During aging, significant amounts of the bone are lost due to the loss of this delicate balance toward increased bone resorption coupled with decreased formation, which leads to ...

journal_title：Advances in experimental medicine and biology

authors： Wei Y,Sun Y

更新日期：2018-01-01 00:00:00

abstract：:Epstein-Barr virus (EBV), which is associated with B-cell proliferative disorders, also transforms T- or natural killer (NK)-lineage cells and has been connected with various T- or NK (T/NK)-cell malignancies, such as extranodal NK/T-cell lymphoma-nasal type and aggressive NK-cell leukemia. Chronic active EBV (CAEBV) ...

journal_title：Advances in experimental medicine and biology

authors： Kimura H

更新日期：2018-01-01 00:00:00

abstract：:HSP-1/2 and PDC-109 belong to a family of fibronectin type II proteins, present in high concentrations in bovine and equine seminal plasma, respectively. These proteins act as extracellular small heat shock proteins and protect target/client proteins against various kinds of stress. They also exhibit characteristic bi...

journal_title：Advances in experimental medicine and biology

authors： Kumar CS,Singh BP,Alim S,Swamy MJ

更新日期：2018-01-01 00:00:00

abstract：:Circular RNAs (circRNAs) are widely present and participate in a variety of biological regulatory activities as a novel type of endogenous noncoding RNA molecule. With advances in RNA structure and function analysis, it was found that circRNAs are present in a myriad of life processes and longevity in model organisms ...

journal_title：Advances in experimental medicine and biology

authors： Yang D,Yang K,Yang M

更新日期：2018-01-01 00:00:00

abstract：:Betaherpesvirus possesses a large genome DNA with a lot of open reading frames, indicating abundance in the variety of viral protein factors. Because the complicated pathogenicity of herpesvirus reflects the combined functions of these factors, analyses of individual proteins are the fundamental steps to comprehensive...

journal_title：Advances in experimental medicine and biology

authors： Nishimura M,Mori Y

更新日期：2018-01-01 00:00:00

abstract：:Studies in Xenopus laevis have greatly contributed to understanding the roles that the Zic family of zinc finger transcription factors play as essential drivers of early development. Explant systems that are not readily available in other organisms give Xenopus embryos a unique place in these studies, facilitated by t...

journal_title：Advances in experimental medicine and biology

authors： Merzdorf C,Forecki J

更新日期：2018-01-01 00:00:00

abstract：:The successful entry of herpes simplex virus (HSV) into a cell is a complex process requiring the interaction of several surface viral glycoproteins with host cell receptors. These viral glycoproteins are currently thought to work sequentially to trigger fusogenic activity, but the process is complicated by the fact t...

journal_title：Advances in experimental medicine and biology

authors： Arii J,Kawaguchi Y

更新日期：2018-01-01 00:00:00

abstract：:Prostate cancer (PCa) is the most common type of cancer in men with high morbidity and mortality. However, the current treatment with drugs often leads to chemotherapy resistance. It is known that the multi-disciplines research on molecular imaging is very helpful for early diagnosing, staging, restaging and precise t...

journal_title：Advances in experimental medicine and biology

authors： Gao T,Bi A,Yang S,Liu Y,Kong X,Zeng W

更新日期：2018-01-01 00:00:00

abstract：:The control of the different angiogenic process is an important point in osteochondral regeneration. Angiogenesis is a prerequisite for osteogenesis in vivo; insufficient neovascularization of bone constructs after scaffold implantation resulted in hypoxia and cellular necrosis. Otherwise, angiogenesis must be avoided...

journal_title：Advances in experimental medicine and biology

authors： García-Fernández L

更新日期：2018-01-01 00:00:00

abstract：:Ankle sprain is amongst the most frequent musculoskeletal injuries, particularly during sports activities. Chronic ankle instability (CAI) resulting from an ankle sprain might have severe long-lasting consequences on the ankle joint. Despite the fact that most patients will respond favourably to appropriate conservati...

journal_title：Advances in experimental medicine and biology

authors： Pereira H,Vuurberg G,Spennacchio P,Batista J,D'Hooghe P,Hunt K,Van Dijk N

更新日期：2018-01-01 00:00:00

abstract：:Cardiovascular diseases are the leading cause of mortality rates throughout the world. Next to an insufficient number of healthy donors, this has led to increasing numbers of patients on heart transplant waiting lists with prolonged waiting times. Innovative technological advancements have led to the production of ven...

journal_title：Advances in experimental medicine and biology

authors： Feldmann C,Chatterjee A,Haverich A,Schmitto JD

更新日期：2018-01-01 00:00:00

abstract：:The carotid body (CB) is organized in clusters of lobules containing type I cells and type II cells, in a ratio of approximately 4:1. The CB undergoes structural and functional changes during perinatal development, in response to a variety of environmental stimuli and in pathological conditions. Knowing that the CB ac...

journal_title：Advances in experimental medicine and biology

authors： Dos Santos E,Sacramento JF,Melo BF,Conde SV

更新日期：2018-01-01 00:00:00

abstract：:How hypoxia regulates gene expression in the human carotid body (CB) remains poorly understood. While limited information on transcriptional regulation in animal CBs is available, the impact of important post-transcriptional regulators, such as non-coding RNAs, and in particular miRNAs is not known. Here we show using...

journal_title：Advances in experimental medicine and biology

authors： Mkrtchian S,Lee KL,Kåhlin J,Ebberyd A,Poellinger L,Fagerlund MJ,Eriksson LI

更新日期：2018-01-01 00:00:00

abstract：:The study investigated a panel of lysosomal enzymes in the liver and kidney tissues in alloxan-induced diabetes in the mouse. The mice were divided into six experimental groups receiving 10% alloxan at a dose of 50 and 75 mg/kg over a period of four, eight, and twelve days; each group was compared with controls receiv...

journal_title：Advances in experimental medicine and biology

authors： Witek B,Rochon-Szmejchel D,Stanisławska I,Łyp M,Wróbel K,Zapała A,Kamińska A,Kołątaj A

更新日期：2018-01-01 00:00:00

abstract：:This chapter illustrates the biostatistical human genetics with an introduction to the T-Test, and the Manhattan Plots in statistics using Human Genetic Data concepts leading to procedures for Statistical Tests and Utilities for Genetic Association. Several R packages are chosen: iGasso, GenABEL, and HardyWeinberg. Ot...

journal_title：Advances in experimental medicine and biology

authors： Chan BKC

更新日期：2018-01-01 00:00:00

abstract：:Prostate cancer causes significant morbidity in men and metastatic disease is a major cause of cancer related deaths. Prostate metastasis is controlled by various cellular intrinsic and extrinsic factors, which are often under the regulatory control of various metastasis-associated genes. Given the dynamic nature of m...

journal_title：Advances in experimental medicine and biology

authors： Bhagirath D,Yang TL,Dahiya R,Saini S

更新日期：2018-01-01 00:00:00

abstract：:Collagen type I is the most abundant matrix protein in the human body and is highly demanded in tissue engineering, regenerative medicine, and pharmaceutical applications. To meet the uprising demand in biomedical applications, collagen type I has been isolated from mammalians (bovine, porcine, goat and rat) and non-m...

journal_title：Advances in experimental medicine and biology

authors： Chowdhury SR,Mh Busra MF,Lokanathan Y,Ng MH,Law JX,Cletus UC,Binti Haji Idrus R

更新日期：2018-01-01 00:00:00

abstract：:Osteoarthritis (OA) is a common form of arthritis, which is characterized by progressive degradation of joint cartilage resulting in pain, joint stiffness, deformity and disability that is also recently related to an increased incidence of mortality. Inhibition of the extracellular matrix (ECM) production by chondrocy...

journal_title：Advances in experimental medicine and biology

authors： Şahin Ş,Tuncel SA,Salimi K,Bilgiç E,Korkusuz P,Korkusuz F

更新日期：2018-01-01 00:00:00

abstract：:Non-coding RNAs mediated core elements of pathways contributes to the disorder of biological function in diseases. Identification of non-coding RNAs mediated subpathways not only can help for deciphering the pathogenic mechanism of complex diseases, but also can gain insight into the functional roles of non-coding RNA...

journal_title：Advances in experimental medicine and biology

authors： Xu Y,Zhang Y,Li X

更新日期：2018-01-01 00:00:00

abstract：:Laminins are major components of all basement membranes surrounding nerve or vascular tissues. In particular laminin-111, the prototype of the family, facilitates a large spectrum of fundamental cellular responses in all eukaryotic cells. Laminin-111 is a biomaterial frequently used in research, however it is primaril...

journal_title：Advances in experimental medicine and biology

authors： Hackethal J,Schuh CMAP,Hofer A,Meixner B,Hennerbichler S,Redl H,Teuschl AH

更新日期：2018-01-01 00:00:00

abstract：:Various commercial vaccines are used for immunization against hepatitis B. However, these immunotherapeutic vaccines require invasive administration, which can induce side effects, and require multiple shots to elicit an immune response, limiting their efficacy. Compared to traditional hepatitis B vaccines, polymer na...

journal_title：Advances in experimental medicine and biology

authors： Hong SJ,Ahn MH,Lee YW,Pal S,Sangshetti J,Arote RB

更新日期：2018-01-01 00:00:00

abstract：:Tissues are often damaged by physical trauma, infection or tumors. A slight injury heals naturally through the normal healing process, while severe injury causes serious health implications. Therefore, many efforts have been devoted to treat and repair various tissue defects. Recently, tissue engineering approaches ha...

journal_title：Advances in experimental medicine and biology

authors： Shin YC,Song SJ,Jeong SJ,Kim B,Kwon IK,Hong SW,Oh JW,Han DW

更新日期：2018-01-01 00:00:00

abstract：:Klebsiella pneumoniae is one of the most important hospital pathogens, particularly concerning the multidrug-resistant strain ESBL+. The aim of this study was to evaluate nosocomial infections with K. pneumoniae ESBL+ in the context of infection location, risk factors, and prognosis. This hospital study was conducted ...

journal_title：Advances in experimental medicine and biology

authors： Starzyk-Łuszcz K,Zielonka TM,Jakubik J,Życińska K

更新日期：2017-01-01 00:00:00

abstract：:The effect of acute exposure to cigarette smoke (CS) on the respiratory system has been less extensively studied than the long term effects of smoking. The aim of the present study was to evaluate the acute response to CS in smokers suffering from chronic obstructive pulmonary disease (COPD) and in healthy smokers. Ni...

journal_title：Advances in experimental medicine and biology

authors： Maskey-Warzęchowska M,Nejman-Gryz P,Osinka K,Lis P,Malesa K,Górska K,Krenke R

更新日期：2017-01-01 00:00:00

abstract：:Antibiotics have long been suspected of contributing to male infertility; however, there are remarkably limited data to support this premise. A major challenge for evaluating antibiotic effects is that the diseases they treat often have negative impacts on male reproduction, so treatment with the antimicrobial can imp...

journal_title：Advances in experimental medicine and biology

authors： Drobnis EZ,Nangia AK

更新日期：2017-01-01 00:00:00

abstract：:Rodent and clinical studies have documented that myeloid cell infiltration of tumors is associated with neutrophilia, lymphocytopenia and poor patient outcomes. This contrasts with lymphocyte infiltration of tumors, which is associated with improved outcomes. Lifestyle parameters such as high fat diet s and omega (ω)-...

journal_title：Advances in experimental medicine and biology

authors： Khadge S,Sharp JG,McGuire TR,Thiele GM,Talmadge JE

更新日期：2017-01-01 00:00:00

abstract：:The central function of renal glomeruli is plasma ultrafiltration for primary urine production. The glomerular filtration barrier consists of a fenestrated endothelium, the glomerular basement membrane and podocytes, mesenchymal-like cells with actin filament-rich protrusions, the "foot processes." Their architecture ...

journal_title：Advances in experimental medicine and biology

authors： Ludwig-Peitsch WK

更新日期：2017-01-01 00:00:00

abstract：:Water permeability is a key feature of the cell plasma membranes and it has seminal importance for a number of cell functions such as cell volume regulation, cell proliferation, cell migration, and angiogenesis to name a few. The transport of water occurs mainly through plasma membrane water channels , the aquaporins,...

journal_title：Advances in experimental medicine and biology

authors： Solenov EI,Baturina GS,Katkova LE,Zarogiannis SG

更新日期：2017-01-01 00:00:00

abstract：:Dendritic spines are the postsynaptic receptive regions of most excitatory synapses in the central nervous system. Thus, spines are supposed to act as a fundamental unit for information processing of the brains. Previous studies have demonstrated the roles of drebrin in the formation of dendritic spines and in the rec...

journal_title：Advances in experimental medicine and biology

authors： Takahashi H,Naito Y

更新日期：2017-01-01 00:00:00

abstract：:In this chapter, we mainly discuss the expression and function of aquaporins (AQPs ) expressed in digestive system . AQPs in gastrointestinal tract include four members of aquaporin subfamily: AQP1, AQP4, AQP5 and AQP8, and a member of aquaglyceroporin subfamily: AQP3. In the digestive glands, especially the liver, we...

journal_title：Advances in experimental medicine and biology

authors： Zhu S,Ran J,Yang B,Mei Z

更新日期：2017-01-01 00:00:00

abstract：:DNA topological transitions occur when replication forks encounter other DNA transactions such as transcription. Failure in resolving such conflicts leads to generation of aberrant replication and transcription intermediates that might have adverse effects on genome stability. Cells have evolved numerous surveillance ...

journal_title：Advances in experimental medicine and biology

authors： Achar YJ,Foiani M

更新日期：2017-01-01 00:00:00

abstract：:Eukaryotic replication proteins are highly conserved, and thus study of Saccharomyces cerevisiae replication can inform about this central process in higher eukaryotes including humans. The S. cerevisiae replisome is a large and dynamic assembly comprised of ~50 proteins. The core of the replisome is composed of 31 di...

journal_title：Advances in experimental medicine and biology

authors： Bai L,Yuan Z,Sun J,Georgescu R,O'Donnell ME,Li H

更新日期：2017-01-01 00:00:00

abstract：:Model organisms are widely used in research that is ultimately aimed at understanding the causes and consequences of human disease. It may seem counterintuitive to expect clinically useful information to be obtained from species as diverse as fishes and insects, but because fundamental biological mechanisms share evol...

journal_title：Advances in experimental medicine and biology

authors： Holt WV

更新日期：2017-01-01 00:00:00

abstract：:In multicellular organisms the fusion of two gametes with a haploid set of chromosomes leads to the formation of the zygote, the first cell of the embryo. Accurate execution of the meiotic cell division to generate a female and a male gamete is required for the generation of healthy offspring harboring the correct num...

journal_title：Advances in experimental medicine and biology

authors： El Yakoubi W,Wassmann K

更新日期：2017-01-01 00:00:00

abstract：:The cells that build the nervous system, either this is a small network of ganglia or a complicated primate brain, are called neural stem and progenitor cells. Even though the very primitive and the very recent neural stem cells (NSCs) share common basic characteristics that are hard-wired within their character, such...

journal_title：Advances in experimental medicine and biology

authors： Andreopoulou E,Arampatzis A,Patsoni M,Kazanis I

更新日期：2017-01-01 00:00:00

abstract：:Hypertension increases the risks of end-organ injury, maternal/fetal vulnerability, and total mortality. Throughout the world, it kills about 7.5 million people every year. During 1975-2015, the number of adults with hypertension increased from 594 million to more than 1.1 billion, mostly due to the increase in the lo...

journal_title：Advances in experimental medicine and biology

authors： Islam MS

更新日期：2017-01-01 00:00:00

abstract：:Diabetes is the leading cause of microalbuminuria and end-stage renal failure in industrial countries. Disruption of the filtration barrier, seen in almost all nephrotic diseases and diabetes, is the result of the loss or effacement of the podocyte foot process, notably damage of proteins within the slit diaphragm suc...

journal_title：Advances in experimental medicine and biology

authors： Denhez B,Geraldes P

更新日期：2017-01-01 00:00:00

abstract：:A wealth of evidence suggests that proteins from prion protein (PrP) family contribute to tumorigenesis in many types of cancers, including pancreatic ductal adenocarcinoma (PDAC), breast cancer, glioblastoma, colorectal cancer, gastric cancer, melanoma, etc. It is well documented that PrP is a biomarker for PDAC, bre...

journal_title：Advances in experimental medicine and biology

authors： Yang X,Cheng Z,Zhang L,Wu G,Shi R,Gao Z,Li C

更新日期：2017-01-01 00:00:00

abstract：:The prognosis for hepatocellular carcinoma (HCC) remains poor and has not improved in over two decades. Most patients with advanced HCC who are not eligible for surgery have limited treatment options due to poor liver function or large, unresectable tumors. Although sorafenib is the standard-of-care treatment for thes...

journal_title：Advances in experimental medicine and biology

authors： Zhao X,Voutila J,Ghobrial S,Habib NA,Reebye V

更新日期：2017-01-01 00:00:00